Which antibiotic is a second-generation fluoroquinolone used in ocular infections?

• A. Ofloxacin
• B. Moxifloxacin
• C. Cefazolin
• D. Gentamicin

Answer: (A)

The main idea is matching the antibiotic to its generation and typical use in the eye. Ofloxacin is a second-generation fluoroquinolone, and this class is valued in ophthalmology for strong activity against common ocular pathogens, including Gram-negative bacteria such as Pseudomonas, as well as good penetration when used topically. This makes it a reliable empirical choice for conjunctivitis and keratitis and a standard example of a second-generation fluoroquinolone in ocular infections.

Moxifloxacin is a later-generation fluoroquinolone with a broader spectrum, cefazolin is a cephalosporin (not a fluoroquinolone), and gentamicin is an aminoglycoside (also not a fluoroquinolone). Thus, Ofloxacin best fits the description of a second-generation fluoroquinolone used in ocular infections.